tag:blogger.com,1999:blog-6232819486261696035.post7120416417363282044..comments2018-10-05T08:05:00.315-05:00Comments on Getting Genetics Done: Epistasis in New PlacesStephen Turnerhttp://www.blogger.com/profile/06656711316726116187noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-6232819486261696035.post-61531493414374982512011-01-12T16:16:48.357-06:002011-01-12T16:16:48.357-06:00The line representing the null hypothesis in that ...The line representing the null hypothesis in that figure does assume that the p-values of interaction terms will be uniformly distributed... However the FDR correction we applied does a dynamic fitting of the null distribution that should account for inflation due to main effects, at least to some degree -- supposedly better than the classic hochberg procedure.<br /><br />I'm not sure I've seen any work describing the theoretical distribution of interaction terms (and p-values) for various genetic models and for cases where the SNPs have independent effects. If you have references please share! There is certainly lots of work to be done in this area.Willhttps://www.blogger.com/profile/09703349044940180835noreply@blogger.comtag:blogger.com,1999:blog-6232819486261696035.post-39680992109132962662010-12-27T09:03:41.096-06:002010-12-27T09:03:41.096-06:00In the QQplot (Figure 1) of your paper, what is th...In the QQplot (Figure 1) of your paper, what is the expected distribution of interaction P-values for pairs of cis-SNPs selected on the basis of an association with the expression trait at p<0.05 ? It appears that you assume that it is the same as in absence of selection.Anonymousnoreply@blogger.com