Monday, September 19, 2016

Primers in computational biology

I recently stumbled across this collection of computational biology primers in Nature Biotechnology. Many of these are old, but they're still great resources to get a fundamental understanding of the topic. Here they are in no particular order.

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How does multiple testing correction work?
http://www.nature.com/nbt/journal/v27/n12/full/nbt1209-1135.html

What is principal component analysis?
http://www.nature.com/nbt/journal/v26/n3/full/nbt0308-303.html

SNP imputation in association studies
http://www.nature.com/nbt/journal/v27/n4/full/nbt0409-349.html

How does gene expression clustering work?
http://www.nature.com/nbt/journal/v23/n12/full/nbt1205-1499.html

What is a hidden Markov model?
http://www.nature.com/nbt/journal/v22/n10/full/nbt1004-1315.html

What is a support vector machine?
http://www.nature.com/nbt/journal/v24/n12/full/nbt1206-1565.html

What is the expectation maximization algorithm?
http://www.nature.com/nbt/journal/v26/n8/full/nbt1406.html

Where did the BLOSUM62 alignment score matrix come from?
http://www.nature.com/nbt/journal/v22/n8/full/nbt0804-1035.html

What are DNA sequence motifs?
http://www.nature.com/nbt/journal/v24/n4/full/nbt0406-423.html

How does DNA sequence motif discovery work?
http://www.nature.com/nbt/journal/v24/n8/full/nbt0806-959.html

What are decision trees?
http://www.nature.com/nbt/journal/v26/n9/full/nbt0908-1011.html

What is dynamic programming?
http://www.nature.com/nbt/journal/v22/n7/full/nbt0704-909.html

What is Bayesian statistics?
http://www.nature.com/nbt/journal/v22/n9/full/nbt0904-1177.html

What are artificial neural networks?
http://www.nature.com/nbt/journal/v26/n2/full/nbt1386.html

How does eukaryotic gene prediction work?
http://www.nature.com/nbt/journal/v25/n8/full/nbt0807-883.html

How to map billions of short reads onto genomes
http://www.nature.com/nbt/journal/v27/n5/full/nbt0509-455.html

How to apply de Bruijn graphs to genome assembly
http://www.nature.com/nbt/journal/v29/n11/full/nbt.2023.html

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