Wednesday, April 14, 2010

Journal Club 4/16/2010

Our Program in Computation Genomics Journal Club is starting again, now the 3rd Friday of each month. The next meeting is this Friday, April 16, at 3pm in the CHGR conference room. As usual, please bring in any articles you've found recently and give a brief overview of why you thought it was interesting. Also, take a look at these papers related to BioVU by investigators at Vanderbilt:


The BioVU demonstration project:

Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record. Am J Hum Genet. 2010 Mar 31.

 

The PheWAS:

Denny JC, Ritchie MD, Basford M, Pulley J, Bastarache L, Brown-Gentry K, Wang D, Masys DR, Roden DM, Crawford DC. PheWAS: Demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics. 2010 Mar 24.



And finally, the PNAS paper from Brad Malin's group, which has generated quite a lot of press (Nature News, Technology Review, Genomics Law Report):


Loukides G, Gkoulalas-Divanis A, Malin B. Anonymization of electronic medical records for validating genome-wide association studies. PNAS.

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